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Peer-reviewed articles

For a comprehensive list of peer reviewed research articles please click on the link to search PubMed.

Schistosomiasis Research Articles on PubMed
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27 Jun 2019

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites

Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. Findings from this study suggest that S. bovis/S. haematobium hybridization occurs rarely, but demonstrate profound consequences of ancient introgression from a livestock parasite into the genome of S. haematobium, the most prevalent schistosome species infecting humans.
Molecular Biology and Evolution
Peer-reviewed article
26 June 2019

Evaluation of integrated interventions layered on mass drug administration for urogenital schistosomiasis elimination: a cluster-randomised trial

Evaluation of a 5-year cluster-randomised trial to assess the effect of different interventions for elimination of urogenital schistosomiasis as a public health problem and interruption of transmission.
The Lancet
Peer-reviewed article
10 June 2019

Report of the 12th meeting of WHO Strategic Technical advisory Group for NTDs

Report and main recommendations of the 12th meeting of the WHO Strategic and Technical Advisory Group (STAG).
WHO/Department of control of Neglected Tropical Diseases
Report
3 June 2019

A Search for Snail-Related Answers to Explain Differences in Response of Schistosoma mansoni to Praziquantel Treatment among Responding and Persistent Hotspot Villages along the Kenyan Shore of Lake Victoria

Investigation of possible inherent differences in snail-related aspects of transmission located along the west-facing shore of the lake and the Winam Gulf. The deeper water snail Biomphalaria choanomphala was significantly more abundant in the PHS villages, and prevalence of S. mansoni among villages both before and after control was positively correlated with B. choanomphala abundance. B. choanomphala provides an alternative, deepwater mode of transmission that may favor greater persistence of S. mansoni in PHS villages.
ASTMH
Peer-reviewed article
31 May 2019

More Medicines Alone Cannot Ensure The Treatment Of Neglected Tropical Diseases.

In this Personal View, we aim to examine the next steps that need to be taken towards ensuring equitable treatment access, including health system integration and the role of endemic countries in ensuring medicines are delivered to patients. We argue that the expansion of medicine donation programmes and the development of new medicines are not the primary solutions to sustaining and expanding the growth of neglected tropical disease programmes. To enable equitable access and efficient use of existing medicines, research is needed now on how best to integrate the treatment of neglected tropical diseases into local health systems. A comprehensive approach should be used, which combines mass drug administration with on-demand access to treatment. Increased commitment by endemic countries, when possible, around the ownership of treatment campaigns is essential to improve access to medicines for neglected tropical diseases.  
The Lancet
Article
24 May 2019

Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways

 Schistosomiasis treatment induces a profound reduction of HIV entry into cervical and blood CD4+ T cells.These findings indicate that Sm therapy may reduce HIV susceptibility for women with S.mansoni infection, potentially through de-repression of IFN-I pathways.
Nature Communications
Peer-reviewed article
23 May 2019

Health Communication Collaborative Online Resources for SBCC

The Health Communication Capacity Collaborative (HC3) designed to online resrouces and tools to  strengthen the capacity of organizations to design, implement and measure their own social and behavior change communication (SBCC) programs.
The Health Communication Capacity Collaborative (HC3)
Tool Kits and Guides
21 May 2019

Meeting report: Accelerating Progress for Schistosomiasis Control and Elimination Post-2020

The Global Schistosomiasis Alliance, hosted by the Ethiopian Federal Ministry of Health and working with the WHO NTD Department, held a consultation meeting with experts and stakeholders to provide feedback on the new proposed WHO goals for schistosomiasis and to discuss and agree on potential sub-targets and indicators for the new NTD Roadmap.
GSA
Report
15 May 2019

In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination

Schistosomiasis is a neglected tropical disease affecting millions of people worldwide. Of the main three species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. This parasite can cause a range of clinical complications associated with bladder pathogenesis, including squamous cell carcinoma as well as genital malignancy in women. Herein, we have performed the first comprehensive characterisation of the proteins implicated in host-parasite interactions (secreted and surface proteins from the adult flukes and secreted and soluble egg proteins) in order to advance our understanding of the parasite’s biology. Furthermore, we have characterised the different antibody responses in urine from infected human subjects from an endemic area presenting different infection intensities. The data obtained in this study can be used as a first step towards the development of novel tools for the control of urogenital schistosomiasis.
PLOS NTDs
Peer-reviewed article
6 May 2019

A 5-Year intervention study on elimination of urogenital schistosomiasis in Zanzibar: Parasitological results of annual cross-sectional surveys.

The Zanzibar Elimination of Schistosomiasis Transmission (ZEST) project implemented from 2011/12 through 2017 aimed to eliminate urogenital schistosomiasis as a public health problem from Pemba and to interrupt S. haematobium transmission from Unguja in 5 years. In a cluster-randomized trial, we investigated the impact of biannual treatment of the population with praziquantel alone or combined with snail control or behavior change interventions. After five years of interventions, the overall S. haematobium prevalence was reduced to <3% in schoolchildren and adults. Heavy infection intensities were observed in <1% of the surveyed population groups. Urogenital schistosomiasis was eliminated as a public health problem from most of the study sites on Pemba and Unguja.
PLOS NTDs
Peer-reviewed article
1 May 2019

WHO Bench aids for the diagnosis of intestinal parasites

This is the second edition of Bench aids for the diagnosis of intestinal parasites, intended both as a practical tool for the diagnosis of intestinal parasitic infections for laboratory and field workers and as a teaching aid for students and trainees.
WHO
Tool Kits and Guides
25 April 2019

Uniting to Combat Action Framework

The Action Framework is a standardized gap analysis tool. It uses qualitative input from stakeholders across the NTD community and fosters dialogue and collective action among a broad set of stakeholders.
Uniting To Combat NTDs
Report

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